Select conditions below to toggle them from the plot:
GROUP | CONDITION | SAMPLES |
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PXR Knockout male mice |
GSM1342744 GSM1342745 GSM1342746 GSM1342747
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GSM1342748 GSM1342749 GSM1342750 GSM1342751
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Wildtype male mice |
GSM1342752 GSM1342753 GSM1342754 GSM1342755
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GSM1342756 GSM1342757 GSM1342758 GSM1342759
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Submission Date: Mar 10, 2014
Summary: Many environmentally-relevant chemicals and drugs activate the nuclear receptor pregnane X receptor (PXR). Activation of PXR can lead to increases in liver weight in part through hepatocyte replication similar to a large number of compounds that activate other nuclear receptors such as the peroxisome proliferator-activated receptor alpha and the constitutive activated receptor (CAR). PXR controls the expression of a large battery of genes involved in xenobiotic metabolism. Identification of genes that are accurate predictors of PXR activation would be useful in high-throughput screens to assess potential toxicity and drug-drug interactions. Here, we identified PXR-dependent genes in the mouse liver after exposure to pregnenolone 16alpha-carbinonitrile (PCN), a chemical that is often used as a model PXR agonist.
GEO Accession ID: GSE55746
PMID: 26215100
Submission Date: Mar 10, 2014
Summary: Many environmentally-relevant chemicals and drugs activate the nuclear receptor pregnane X receptor (PXR). Activation of PXR can lead to increases in liver weight in part through hepatocyte replication similar to a large number of compounds that activate other nuclear receptors such as the peroxisome proliferator-activated receptor alpha and the constitutive activated receptor (CAR). PXR controls the expression of a large battery of genes involved in xenobiotic metabolism. Identification of genes that are accurate predictors of PXR activation would be useful in high-throughput screens to assess potential toxicity and drug-drug interactions. Here, we identified PXR-dependent genes in the mouse liver after exposure to pregnenolone 16alpha-carbinonitrile (PCN), a chemical that is often used as a model PXR agonist.
GEO Accession ID: GSE55746
PMID: 26215100
Signatures:
Control Condition
Perturbation Condition
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