GSE226888: The effect of DFMO on the gene expression in pro-inflammatory cytokine-treated human islets

Gene Expression Data Explorer
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GROUP CONDITION SAMPLES
Human islets from cadaveric organ donors
GSM7086408 GSM7086409 GSM7086410 GSM7086411 GSM7086412
GSM7086403 GSM7086404 GSM7086405 GSM7086406 GSM7086407
GSM7086393 GSM7086394 GSM7086395 GSM7086396 GSM7086397
GSM7086398 GSM7086399 GSM7086400 GSM7086401 GSM7086402
Description

Submission Date: Mar 07, 2023

Summary: Inhibition of polyamine biosynthesis using α-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), reduces β-cell stress and type 1 diabetes (T1D) incidence in preclinical models. However, underlying cellular and molecular mechanisms and the tolerability and effectiveness of polyamine depletion by DFMO in humans with T1D remain unknown. Transcriptomics and proteomics of cytokine-stressed human islets treated with DFMO reveal alterations in mRNA translation, nascent protein transport, and secretion. Collectively, our data suggest that inhibition of polyamine biosynthesis may preserve β-cell function in T1D via islet cell-autonomous responses to stress.

GEO Accession ID: GSE226888

PMID: No Pubmed ID

Description

Submission Date: Mar 07, 2023

Summary: Inhibition of polyamine biosynthesis using α-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), reduces β-cell stress and type 1 diabetes (T1D) incidence in preclinical models. However, underlying cellular and molecular mechanisms and the tolerability and effectiveness of polyamine depletion by DFMO in humans with T1D remain unknown. Transcriptomics and proteomics of cytokine-stressed human islets treated with DFMO reveal alterations in mRNA translation, nascent protein transport, and secretion. Collectively, our data suggest that inhibition of polyamine biosynthesis may preserve β-cell function in T1D via islet cell-autonomous responses to stress.

GEO Accession ID: GSE226888

PMID: No Pubmed ID

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