GSE197850: Glucagon-like Peptide-1 (GLP-1) Rescue Diabetic Cardiac Dysfuntions in Human iPSC-Derived Cardiomyocytes

Gene Expression Data Explorer
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GROUP CONDITION SAMPLES
induced pluripotent stem cells-derived cardiomyocytes (iPSC-CMs)
GSM5931369 GSM5931370 GSM5931371 GSM5931372
GSM5931365 GSM5931366 GSM5931367 GSM5931368
GSM5931377 GSM5931378 GSM5931379 GSM5931380
GSM5931373 GSM5931374 GSM5931375 GSM5931376
Description

Submission Date: Mar 03, 2022

Summary: We investigate the effects of GLP-1 on diabetic cardiomyocytes (DCMs) model established by human induced pluripotent stem cells-derived cardiomyocytes (iPSC-CMs). Two subtypes of GLP-1, GLP-17-36 and GLP-19-36, were evaluated for their efficacy on hypertrophic phenotype, impaired calcium homeostasis and electrophysiological properties. RNA-seq was performed to reveal the underlying molecular mechanism of GLP-1. Our results demonstrated that GLP-17-36 and GLP-19-36 were able to ameliorate high glucose-induced hypertrophy phenotype and cardiac dysfunctions in DCM model based on iPSC-CMs. Our study provides a novel platform to unveil the cellular mechanisms of diabetic cardiomyopathy, which sheds light on discovering better targets for novel therapeutic interventions.

GEO Accession ID: GSE197850

PMID: No Pubmed ID

Description

Submission Date: Mar 03, 2022

Summary: We investigate the effects of GLP-1 on diabetic cardiomyocytes (DCMs) model established by human induced pluripotent stem cells-derived cardiomyocytes (iPSC-CMs). Two subtypes of GLP-1, GLP-17-36 and GLP-19-36, were evaluated for their efficacy on hypertrophic phenotype, impaired calcium homeostasis and electrophysiological properties. RNA-seq was performed to reveal the underlying molecular mechanism of GLP-1. Our results demonstrated that GLP-17-36 and GLP-19-36 were able to ameliorate high glucose-induced hypertrophy phenotype and cardiac dysfunctions in DCM model based on iPSC-CMs. Our study provides a novel platform to unveil the cellular mechanisms of diabetic cardiomyopathy, which sheds light on discovering better targets for novel therapeutic interventions.

GEO Accession ID: GSE197850

PMID: No Pubmed ID

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Bulk RNA-seq Appyter

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