Gene counts are sourced from ARCHS4, which provides uniform alignment of GEO samples.
You can learn more about ARCHS4 and its pipeline here.
Select conditions below to toggle them from the plot:
| GROUP | CONDITION | SAMPLES |
|---|---|---|
| bladder cancer cell line 5637 |
GSM4579766 GSM4579768 GSM4579770
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|
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GSM4579765 GSM4579767 GSM4579769
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||
| bladder cancer cell line CLS-439 |
GSM4579778 GSM4579780 GSM4579782
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|
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GSM4579777 GSM4579779 GSM4579781
|
||
| bladder cancer cell line T24 |
GSM4579760 GSM4579762 GSM4579764
|
|
|
GSM4579759 GSM4579761 GSM4579763
|
||
| bladder cancer cell line TCC-SUP |
GSM4579772 GSM4579774 GSM4579776
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GSM4579771 GSM4579773 GSM4579775
|
Submission Date: May 30, 2020
Summary: Mitomycin C (MMC) is the gold standard treatment for non-muscle invasive bladder cancer (NMIBC). We aimed to evaluate in bladder cancer cell lines (T24, 5637, TCC-SUP and CLS-439) the transcriptomic response to MMC treatment. We used Gene Set Enrichment Analysis (GSEA) to identify biological processes and pathways modulated by MMC treatment.
GEO Accession ID: GSE151505
PMID: 33408185
Submission Date: May 30, 2020
Summary: Mitomycin C (MMC) is the gold standard treatment for non-muscle invasive bladder cancer (NMIBC). We aimed to evaluate in bladder cancer cell lines (T24, 5637, TCC-SUP and CLS-439) the transcriptomic response to MMC treatment. We used Gene Set Enrichment Analysis (GSEA) to identify biological processes and pathways modulated by MMC treatment.
GEO Accession ID: GSE151505
PMID: 33408185
Visualizations are precomputed using the Python package scanpy on the top 5000 most variable genes.
Differential expression signatures are automatically computed using the limma R package.
More options for differential expression are available to compute below.
Signatures:
Control Condition
Perturbation Condition
Only conditions with at least 1 replicate are available to select
Differential expression signatures can be computed using DESeq2 or characteristic direction.
This pipeline enables you to analyze and visualize your bulk RNA sequencing datasets with an array of downstream analysis and visualization tools. The pipeline includes: PCA analysis, Clustergrammer interactive heatmap, library size analysis, differential gene expression analysis, enrichment analysis, and L1000 small molecule search.