GSE136396: RNASeq of cold-sensitive and cold-insensitive neurons from the pre-optic area of hypothalamus of mice

Gene Expression Data Explorer
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GROUP CONDITION SAMPLES
Neurons from the pre-optic area of hypothalamus
GSM4048025 GSM4048026 GSM4048027
GSM4048022 GSM4048023 GSM4048024
Description

Submission Date: Aug 27, 2019

Summary: The preoptic area of the hypothalamus (POA) contains intrinsically warm and cold-sensitive neurons, which are thought to be critically involved in mammalian thermoregulation. However, the precise physiological roles and the molecular markers of the cold-sensitive POA neurons have not been determined yet. Here, we tackle this problem by performing calcium-imaging guided separation and collection of cold-sensitive and cold-insensitive dissociated neurons from the mouse POA, followed by RNASeq and differential transcriptomics of these cell populations.

GEO Accession ID: GSE136396

PMID: 32270761

Description

Submission Date: Aug 27, 2019

Summary: The preoptic area of the hypothalamus (POA) contains intrinsically warm and cold-sensitive neurons, which are thought to be critically involved in mammalian thermoregulation. However, the precise physiological roles and the molecular markers of the cold-sensitive POA neurons have not been determined yet. Here, we tackle this problem by performing calcium-imaging guided separation and collection of cold-sensitive and cold-insensitive dissociated neurons from the mouse POA, followed by RNASeq and differential transcriptomics of these cell populations.

GEO Accession ID: GSE136396

PMID: 32270761

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Precomputed Differential Gene Expression

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Differential Gene Expression Analysis
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Bulk RNA-seq Appyter

This pipeline enables you to analyze and visualize your bulk RNA sequencing datasets with an array of downstream analysis and visualization tools. The pipeline includes: PCA analysis, Clustergrammer interactive heatmap, library size analysis, differential gene expression analysis, enrichment analysis, and L1000 small molecule search.