Select conditions below to toggle them from the plot:
GROUP | CONDITION | SAMPLES |
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Female subjects |
GSM4037903 GSM4037905 GSM4037909 GSM4037911 GSM4037915 GSM4037919 GSM4037925 GSM4037927 GSM4037929 GSM4037933 GSM4037941
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GSM4037904 GSM4037906 GSM4037910 GSM4037912 GSM4037916 GSM4037920 GSM4037926 GSM4037928 GSM4037930 GSM4037934 GSM4037942
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Male subjects |
GSM4037897 GSM4037899 GSM4037901 GSM4037907 GSM4037913 GSM4037917 GSM4037921 GSM4037923 GSM4037931 GSM4037935 GSM4037937 GSM4037939 GSM4037943
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GSM4037898 GSM4037900 GSM4037902 GSM4037908 GSM4037914 GSM4037918 GSM4037922 GSM4037924 GSM4037932 GSM4037936 GSM4037938 GSM4037940 GSM4037944
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Mixed female & male subjects |
GSM4037879 GSM4037880 GSM4037881 GSM4037882 GSM4037883 GSM4037884 GSM4037885 GSM4037886
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GSM4037887 GSM4037888 GSM4037889 GSM4037890 GSM4037891 GSM4037892 GSM4037893 GSM4037894 GSM4037895 GSM4037896
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Submission Date: Aug 16, 2019
Summary: Obstructive sleep apnea (OSA) has been linked to dysregulated metabolic states and treatment of sleep apnea may improve these conditions. Subcutaneous adipose tissue is a readily samplable fat depot that plays an important role in regulating metabolism. However, neither the pathophysiologic consequences of OSA nor the effects of continuous positive airway pressure (CPAP) in altering this compartment's molecular pathways are understood. This study aimed to systematically identify subcutaneous adipose tissue transcriptional programs modulated in OSA and in response to its effective treatment with CPAP. Two subject groups were investigated: Study Group 1 was comprised of 10 OSA and 8 controls; Study Group 2 included 24 individuals with OSA studied at baseline and following CPAP. For each subject, genome-wide gene expression measurement of subcutaneous fat was performed. Differentially activated pathways elicited by OSA (Group 1) and in response to its treatment (Group 2) were determined using network and Gene Set Enrichment Analysis (GSEA). In Group 2, treatment of OSA with CPAP improved apnea hypopnea index, daytime sleepiness, and blood pressure, but not anthropometric measures. In Group 1, GSEA revealed many up-regulated gene sets in OSA subjects, most of which were involved in immuno-inflammatory (e.g., interferon-γ signaling), transcription, and metabolic processes such as adipogenesis. Unexpectedly, CPAP therapy in Group 2 subjects was also associated with up-regulation of several immune pathways as well as cholesterol biosynthesis. Collectively, our findings demonstrate that OSA alters distinct inflammatory and metabolic programs in subcutaneous fat, but these transcriptional signatures are not reversed with short-term effective therapy.
GEO Accession ID: GSE135917
PMID: 31872261
Submission Date: Aug 16, 2019
Summary: Obstructive sleep apnea (OSA) has been linked to dysregulated metabolic states and treatment of sleep apnea may improve these conditions. Subcutaneous adipose tissue is a readily samplable fat depot that plays an important role in regulating metabolism. However, neither the pathophysiologic consequences of OSA nor the effects of continuous positive airway pressure (CPAP) in altering this compartment's molecular pathways are understood. This study aimed to systematically identify subcutaneous adipose tissue transcriptional programs modulated in OSA and in response to its effective treatment with CPAP. Two subject groups were investigated: Study Group 1 was comprised of 10 OSA and 8 controls; Study Group 2 included 24 individuals with OSA studied at baseline and following CPAP. For each subject, genome-wide gene expression measurement of subcutaneous fat was performed. Differentially activated pathways elicited by OSA (Group 1) and in response to its treatment (Group 2) were determined using network and Gene Set Enrichment Analysis (GSEA). In Group 2, treatment of OSA with CPAP improved apnea hypopnea index, daytime sleepiness, and blood pressure, but not anthropometric measures. In Group 1, GSEA revealed many up-regulated gene sets in OSA subjects, most of which were involved in immuno-inflammatory (e.g., interferon-γ signaling), transcription, and metabolic processes such as adipogenesis. Unexpectedly, CPAP therapy in Group 2 subjects was also associated with up-regulation of several immune pathways as well as cholesterol biosynthesis. Collectively, our findings demonstrate that OSA alters distinct inflammatory and metabolic programs in subcutaneous fat, but these transcriptional signatures are not reversed with short-term effective therapy.
GEO Accession ID: GSE135917
PMID: 31872261
Signatures:
Control Condition
Perturbation Condition
Only conditions with at least 1 replicate are available to select