GSE134431: Deregulated immune signature orchestrated by FOXM1 impairs human diabetic wound healing

Gene Expression Data Explorer
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GROUP CONDITION SAMPLES
Diabetic foot
GSM3946500 GSM3946501 GSM3946502 GSM3946503 GSM3946504 GSM3946505
GSM3946485 GSM3946486 GSM3946487 GSM3946488 GSM3946489 GSM3946490 GSM3946491 GSM3946492
GSM3946493 GSM3946494 GSM3946495 GSM3946496 GSM3946497 GSM3946498 GSM3946499
Description

Submission Date: Jul 17, 2019

Summary: We performed RNA-seq on tissue biopsies derived from patients with DFUs and compared it to human oral and skin wounds to identify the molecular mechanisms and transcriptional networks that are deregulated in DFUs. Our results identified a unique inflammatory transcriptional signature unique to oral and skin wounds involved in promoting cell proliferation and cell survival of immune cells that are deficient in DFUs. In addition, we identified a signature immune-cell profile in which activation and proliferation of macrophages and neutrophils were absent in DFUs. These results suggest that a deregulated immune response in which impaired activation, proliferation and survival of immune cells contribute to pathogenesis of DFUs and provides novel avenues for development of therapies aimed at reprogramming DFUs into healing-competent wounds.

GEO Accession ID: GSE134431

PMID: 32938916

Description

Submission Date: Jul 17, 2019

Summary: We performed RNA-seq on tissue biopsies derived from patients with DFUs and compared it to human oral and skin wounds to identify the molecular mechanisms and transcriptional networks that are deregulated in DFUs. Our results identified a unique inflammatory transcriptional signature unique to oral and skin wounds involved in promoting cell proliferation and cell survival of immune cells that are deficient in DFUs. In addition, we identified a signature immune-cell profile in which activation and proliferation of macrophages and neutrophils were absent in DFUs. These results suggest that a deregulated immune response in which impaired activation, proliferation and survival of immune cells contribute to pathogenesis of DFUs and provides novel avenues for development of therapies aimed at reprogramming DFUs into healing-competent wounds.

GEO Accession ID: GSE134431

PMID: 32938916

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