GSE124621: PGRMC2 is an Intracellular Heme Chaperone Critical for Adipocyte Function

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Brown Adipose Tissue
GSM3538042 GSM3538043 GSM3538044 GSM3538045
GSM3538046 GSM3538047 GSM3538048 GSM3538049
Description

Submission Date: Jan 03, 2019

Summary: We describe a role for the poorly annotated protein PGRMC2 in retrograde transport of heme from mitochondria to the nucleus. In absence of PGRMC2, less signaling heme reaches the nucleus, with a consequent alteration of heme-sensitive transcriptional programs that ultimately engenders severe mitochondrial dysfunction in brown adipocytes. These mitochondrial defects compromise, not only the primary function of BAT, to activate thermogenesis and preserve body temperature, but also its contribution to maintain systemic glucose and lipid homeostasis.

GEO Accession ID: GSE124621

PMID: 31748741

Description

Submission Date: Jan 03, 2019

Summary: We describe a role for the poorly annotated protein PGRMC2 in retrograde transport of heme from mitochondria to the nucleus. In absence of PGRMC2, less signaling heme reaches the nucleus, with a consequent alteration of heme-sensitive transcriptional programs that ultimately engenders severe mitochondrial dysfunction in brown adipocytes. These mitochondrial defects compromise, not only the primary function of BAT, to activate thermogenesis and preserve body temperature, but also its contribution to maintain systemic glucose and lipid homeostasis.

GEO Accession ID: GSE124621

PMID: 31748741

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