GSE114192: Immune dysfunction in intermediate hyperglycaemia and diabetes patients in tuberculosis

Gene Expression Data Explorer
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GROUP CONDITION SAMPLES
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GSM3137415 GSM3137419 GSM3137424 GSM3137425 GSM3137429 GSM3137435 GSM3137437 GSM3137441 GSM3137444 GSM3137445 GSM3137446 GSM3137447 GSM3137457 GSM3137470 GSM3137478 GSM3137484 GSM3137490 GSM3137492 GSM3137505 GSM3137506 GSM3137510 GSM3137533 GSM3137546 GSM3137548 GSM3137552 GSM3137561 GSM3137563 GSM3137569 GSM3137575 GSM3137576 GSM3137586 GSM3137593 GSM3137596 GSM3137599 GSM3137601 GSM3137609 GSM3137614 GSM3137619 GSM3137622 GSM3137629 GSM3137637 GSM3137639 GSM3137640 GSM3137654
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GSM3137459 GSM3137476 GSM3137482 GSM3137486 GSM3137500 GSM3137551 GSM3137564 GSM3137572 GSM3137605 GSM3137650
GSM3137416 GSM3137422 GSM3137427 GSM3137428 GSM3137443 GSM3137452 GSM3137453 GSM3137458 GSM3137472 GSM3137481 GSM3137485 GSM3137488 GSM3137493 GSM3137495 GSM3137496 GSM3137499 GSM3137513 GSM3137514 GSM3137515 GSM3137522 GSM3137523 GSM3137525 GSM3137526 GSM3137527 GSM3137534 GSM3137537 GSM3137538 GSM3137547 GSM3137556 GSM3137559 GSM3137562 GSM3137565 GSM3137566 GSM3137571 GSM3137580 GSM3137591 GSM3137594 GSM3137595 GSM3137597 GSM3137598 GSM3137608 GSM3137612 GSM3137615 GSM3137621 GSM3137628 GSM3137631 GSM3137633 GSM3137642 GSM3137643 GSM3137653 GSM3137656 GSM3137659
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Description

Submission Date: May 08, 2018

Summary: People living with diabetes have an increased risk of developing active tuberculosis. The effects of diabetes (HbA1c ≥6.5%) and intermediate hyperglycaemia (HbA1c 5.7-6.5%), on this transcriptomic signature were investigated by RNA-seq, to enhance understanding of immunological susceptibility in diabetes-tuberculosis comorbidity.Diabetes increased the magnitude of gene expression change in the host transcriptome in tuberculosis, characterised by an increase in innate, and decrease in adaptive immune responses. Strikingly, patients with intermediate hyperglycaemia and tuberculosis exhibited blood transcriptomes much more similar to diabetes-tuberculosis patients than to uncomplicated tuberculosis patients. Aberrant transcriptomes unveil a susceptibility mechanism of DM patients to TB of enhanced inflammation and reduced interferon responses.

GEO Accession ID: GSE114192

PMID: 32533832

Description

Submission Date: May 08, 2018

Summary: People living with diabetes have an increased risk of developing active tuberculosis. The effects of diabetes (HbA1c ≥6.5%) and intermediate hyperglycaemia (HbA1c 5.7-6.5%), on this transcriptomic signature were investigated by RNA-seq, to enhance understanding of immunological susceptibility in diabetes-tuberculosis comorbidity.Diabetes increased the magnitude of gene expression change in the host transcriptome in tuberculosis, characterised by an increase in innate, and decrease in adaptive immune responses. Strikingly, patients with intermediate hyperglycaemia and tuberculosis exhibited blood transcriptomes much more similar to diabetes-tuberculosis patients than to uncomplicated tuberculosis patients. Aberrant transcriptomes unveil a susceptibility mechanism of DM patients to TB of enhanced inflammation and reduced interferon responses.

GEO Accession ID: GSE114192

PMID: 32533832

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