GSE112213: Next Generation Sequencing of LdlrKO LXRα-phosphorylation disrupted macrophage transcriptomes

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GROUP CONDITION SAMPLES
mice 20 weeks old
GSM3061031 GSM3061032 GSM3061033
GSM3061037 GSM3061038 GSM3061039
GSM3061028 GSM3061029 GSM3061030
GSM3061034 GSM3061035
GSM3061036
Description

Submission Date: Mar 22, 2018

Summary: Liver X Receptors (LXRα and β) are ligand-activated transcription factors that play a key role in the control of lipid homeostasis, as well as modulation of immunity and inflammation. Besides ligand binding, LXR activity can be regulated by posttranslational modifications, such as phosphorylation. This study aims to assess changes in bone marrow derived macrophage transcriptional profiles of mice that carry LysMcre directed phosphorylation deficient-version of LXRα compared (S196A) to wild-type (WT).

GEO Accession ID: GSE112213

PMID: 29950315

Description

Submission Date: Mar 22, 2018

Summary: Liver X Receptors (LXRα and β) are ligand-activated transcription factors that play a key role in the control of lipid homeostasis, as well as modulation of immunity and inflammation. Besides ligand binding, LXR activity can be regulated by posttranslational modifications, such as phosphorylation. This study aims to assess changes in bone marrow derived macrophage transcriptional profiles of mice that carry LysMcre directed phosphorylation deficient-version of LXRα compared (S196A) to wild-type (WT).

GEO Accession ID: GSE112213

PMID: 29950315

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